Affiliation:
1. Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands.
2. Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK
Abstract
Medicinal chemists are under increasing pressure, not only to identify lead compounds and optimize them into clinical candidates, but also to produce materials in sufficient quantities for subsequent investigation. With this in mind, continuous-flow methodology presents an opportunity to reduce the time taken to, first, identify the compound and, second, scale the process for evaluation and, where necessary, production. It is therefore the aim of this review to provide the reader with an insight into the advantages associated with the use of continuous-flow chemistry through the use of strategically selected literature examples.
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
37 articles.
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