Structure analysis reveals the flexibility of the ADAMTS-5 active site-Reference-Cited by-同舟云学术

Structure analysis reveals the flexibility of the ADAMTS-5 active site

Published:2011-03-22 Issue:4 Volume:20 Page:735-744
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Shieh Huey-Sheng,Tomasselli Alfredo G.,Mathis Karl J.,Schnute Mark E.,Woodard Scott S.,Caspers Nicole,Williams Jennifer M.,Kiefer James R.,Munie Grace,Wittwer Arthur,Malfait Anne-Marie,Tortorella Micky D.

Funder

U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences

Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.606/fullpdf

Reference21 articles.

1. Drug insight: aggrecanases as therapeutic targets for osteoarthritis;Fosang;Nat Clin Pract Rheumatol,2008

2. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis;Glasson;Nature,2005

3. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro;Stanton;Nature,2005

4. ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes;Botter;Osteoarthr Cartil,2009

5. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization;Malfait;Osteoarthr Cartil,2010

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