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Understanding the variability of the S1′ pocket to improve matrix metalloproteinase inhibitor selectivity profiles

  • Published:2020-01 Issue:1 Volume:25 Page:38-57
  • ISSN:1359-6446
  • Container-title:Drug Discovery Today
  • language:en
  • Short-container-title:Drug Discovery Today

Author:

Gimeno Aleix,Beltrán-Debón Raúl,Mulero Miquel,Pujadas Gerard,Garcia-Vallvé Santiago

Funder

Universitat Rovira i Virgili

Government of Catalonia

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference99 articles.

1. Matrix metalloproteinases: fold and function of their catalytic domains;Tallant;Biochim. Biophys. Acta Mol. Cell Res.,2010

2. MMP Inhibitors: past, present and future;Cathcart;Front. Biosci.,2015

3. Is there new hope for therapeutic matrix metalloproteinase inhibition?;Vandenbroucke;Nat. Rev. Drug Discov.,2014

4. Historical perspective of matrix metalloproteases;Pulkoski-Gross;Front. Biosci.,2015

5. Matrix metalloproteinase inhibitors: a patent review (2011–2013);Li;Expert Opin. Ther. Pat.,2014
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