Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points-Reference-Cited by-同舟云学术

Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points

Published:2024-01-12 Issue:2 Volume:67 Page:1406-1420
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oka Yusuke¹^ORCID,Abe-Sato Kumi¹^ORCID,Tabuse Hideaki¹^ORCID,Yasukawa Yoshifumi¹,Yahara Tohru²^ORCID,Nishimoto Tomohiro²,Kamitani Masafumi³,Fukunaga Takuya³,Ochiai Nagahiro³,Kumasaka-Abe Tomoko³,Hitaka Kosuke⁴,Gunji Emi⁴,Ohara Hiroki⁴,Takeda Takuya⁴,Kojima Naoki⁴,Asami Taiji¹^ORCID

Affiliation:

1. Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan

2. Drug Metabolism and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan

3. Discovery Technologies Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan

4. Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01967

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