On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis-Reference-Cited by-同舟云学术

On-demand release of a selective MMP-13 blocker from an enzyme-responsive injectable hydrogel protects cartilage from degenerative progression in osteoarthritis

Published:2024 Issue:22 Volume:12 Page:5325-5338
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Roy Himadri Shekhar¹,Murugesan Preethi¹,Kulkarni Chirag²,Arora Malika¹,Nagar Geet Kumar²,Guha Rajdeep³^ORCID,Chattopadhyay Naibedya²^ORCID,Ghosh Deepa¹^ORCID

Affiliation:

1. Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali-140306, Punjab, India

2. Division of Endocrinology and Centre for Research in ASTHI, CSIR-Central Drug Research Institute, Lucknow–226031, Uttar Pradesh, India

3. Division of Laboratory Animal Facility, CSIR-Central Drug Research Institute, Lucknow–226031, Uttar Pradesh, India

Abstract

Release of BI-4394, a MMP-13 inhibitor, from an enzyme-responsive hydrogel protects cartilage from progressive degeneration in an ACLT rat model.

Funder

Science and Engineering Research Board

Central Drug Research Institute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02871B

Reference91 articles.

1. The collagens of articular cartilage

2. Articular cartilage collagen: an irreplaceable framework?

3. THE DISTRIBUTION OF COLLAGEN IN HUMAN ARTICULAR CARTILAGE WITH SOME OF ITS PHYSIOLOGICAL IMPLICATIONS

4. The Bioactivity of Cartilage Extracellular Matrix in Articular Cartilage Regeneration

5. The articular cartilage surface is impaired by a loss of thick collagen fibers and formation of type I collagen in early osteoarthritis

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