An industrial perspective on contemporary applications of PBPK models in drug discovery and development

Author:

Smith Bill J.1

Affiliation:

1. Pfizer, Inc.; Worldwide Research and Development, La Jolla Laboratories; San Diego; CA; USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference8 articles.

1. PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach;Poulin;J Pharm Sci,2012

2. http://www.simcyp.com/AboutUs/TheConsortium/

3. http://iqconsortium.com/

4. Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling;Jones;Clin Pharmacokinet,2011

5. Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: physiologically based pharmacokinetic model versus traditional one-compartment model;Yamazaki;Drug Metab Dispos,2011

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