Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanisticin vitro-in vivoextrapolation of oral drug absorption

Author:

Harwood M. D.,Neuhoff S.1,Carlson G. L.2,Warhurst G.2,Rostami-Hodjegan A.

Affiliation:

1. Simcyp Ltd (a Certara Company); Blades Enterprise Centre; Sheffield; S2 4SU; UK

2. Gut Barrier Group, School of Translational Medicine; University of Manchester, Salford Royal Hospital NHS Trust; M6 8HD; UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference145 articles.

1. PBPK as a tool in regulatory review;Huang;Biopharm Drug Dispos,2012

2. Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!;Rostami-Hodjegan;Biopharm Drug Dispos,2012

3. An industrial perspective on contemporary applications of PBPK models in drug discovery and development;Smith;Biopharm Drug Dispos,2012

4. Membrane transporters in drug development;Giacomini;Nat Rev Drug Discov,2010

5. CHMP Guidance on the Investigation of Drug Interactions 2012 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf

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