Interspecies prediction of oral pharmacokinetics of different lacidipine formulations from dogs to human: physiologically based pharmacokinetic modelling combined with biorelevant dissolution-Reference-Cited by-同舟云学术

Interspecies prediction of oral pharmacokinetics of different lacidipine formulations from dogs to human: physiologically based pharmacokinetic modelling combined with biorelevant dissolution

Published:2015 Issue:26 Volume:5 Page:19844-19852
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wu Chunnuan¹²³⁴⁵,Kou Longfa¹²³⁴⁵,Ma Panqin⁶⁵,Gao Lifang¹²³⁴⁵,Li Bo¹²³⁴⁵,Li Ran¹²³⁴⁵,Luo Cong¹²³⁴⁵,Shentu Jianzhong⁷⁸⁵,He Zhonggui¹²³⁴⁵,Sun Jin¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutics

2. School of Pharmacy

3. Shenyang Pharmaceutical University

4. Shenyang 110016

5. China

6. Kangya of Ningxia Pharmaceuticals Co. Ltd

7. The First Affiliated Hospital of College of Medicine

8. Zhejiang University

Abstract

PBPK modelling combined with biorelevant dissolution to quantitatively predict dog PK of different lacidipine formulations, and to extrapolate to human.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA16017G

Reference33 articles.

1. In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs

2. The Biopharmaceutics Classification System: Subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC

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