Design of a New Substituted 2,4-Diamino-5-benzylpyrimidine as Inhibitor of Bacterial Dihydrofolate Reductase Assisted by Molecular Graphics
Author:
Publisher
Wiley
Subject
Pharmacology
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1. Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicansSynthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4‘-Substituted 4-Aminodiphenyl Sulfones;Journal of Medicinal Chemistry;2003-12-02
2. Partial resistance of E. coli mutants against 2,4-diamino-5-benzylpyrimidines by interactions with bacterial membrane lipopolysaccharides. Derivation of quantitative structure–binding relationships;European Journal of Medicinal Chemistry;2000-06
3. Nonlinear CoMFA using QPLS as a Novel 3D-QSAR Approach;Quantitative Structure-Activity Relationships;1997
4. New Antifolate 4,4′-Diaminodiphenyl Sulfone Substituted 2,4-Diamino-5-benzylpyrimidines. Proof of Their Dual Mode of Action and Autosynergism;Archiv der Pharmazie;1996
5. New benzylpyrimidines: inhibition of DHFR from various species. QSAR, CoMFA and PC analysis;European Journal of Medicinal Chemistry;1995-01
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