Design of a New Substituted 2,4-Diamino-5-benzylpyrimidine as Inhibitor of Bacterial Dihydrofolate Reductase Assisted by Molecular Graphics
Author:
Publisher
Wiley
Subject
Pharmacology
Reference13 articles.
1. Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate
2. Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs
3. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicansSynthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4‘-Substituted 4-Aminodiphenyl Sulfones;Journal of Medicinal Chemistry;2003-12-02
2. Partial resistance of E. coli mutants against 2,4-diamino-5-benzylpyrimidines by interactions with bacterial membrane lipopolysaccharides. Derivation of quantitative structure–binding relationships;European Journal of Medicinal Chemistry;2000-06
3. Nonlinear CoMFA using QPLS as a Novel 3D-QSAR Approach;Quantitative Structure-Activity Relationships;1997
4. New Antifolate 4,4′-Diaminodiphenyl Sulfone Substituted 2,4-Diamino-5-benzylpyrimidines. Proof of Their Dual Mode of Action and Autosynergism;Archiv der Pharmazie;1996
5. New benzylpyrimidines: inhibition of DHFR from various species. QSAR, CoMFA and PC analysis;European Journal of Medicinal Chemistry;1995-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3