Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate-Reference-Cited by-同舟云学术

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Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

Published:1977-07-29 Issue:4302 Volume:197 Page:452-455
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Matthews D. A.¹,Alden R. A.¹,Bolin J. T.¹,Freer S. T.¹,Hamlin R.²,Xuong N.¹²³,Kraut J.¹,Poe M.⁴,Williams M.⁴,Hoogsteen K.⁴

Affiliation:

1. Department of Chemistry, University of California, San Diego, La Jolla 92093

2. Department of Physics, University of California, San Diego, La Jolla 92093

3. Department of Biology, University of California, San Diego, La Jolla 92093

4. Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. ADAMS, M.J., STRUCTURE-FUNCTION RELATIONSHIPS IN LACTATE-DEHYDROGENASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 1968 (1973).

2. Baker, B. R., Design ofActive-Site Directed Irreversible Enzyme Inhibitors: 192 (1967).

3. COMMUNICATION

4. BENNETT, C.D., SIMILARITY IN SEQUENCE OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE WITH OTHER PYRIDINE NUCLEOTIDE REQUIRING ENZYMES, NATURE 248: 67 (1974).

5. Bertino, J. R., Cancer Chemotherapy 2: 9 (1972).

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