Development of a detection method for antisense oligonucleotides in mouse kidneys by matrix-assisted laser desorption/ionization imaging mass spectrometry
Author:
Affiliation:
1. Otsuka Pharmaceutical Co., Ltd, Tokushima Research Institute; Tokushima Japan
2. Graduate School of Pharmaceutical Sciences; Osaka University; Osaka Japan
3. National Institutes of Biomedical Innovation, Health and Nutrition; Osaka Japan
Publisher
Wiley
Subject
Organic Chemistry,Spectroscopy,Analytical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/rcm.8274/fullpdf
Reference32 articles.
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2. Locked nucleic acid oligonucleotides: The next generation of antisense agents?;Grunweller;BioDrugs,2007
3. Phosphorothioates, essential components of therapeutic oligonucleotides;Eckstein;Nucleic Acid Ther,2014
4. Design of antisense oligonucleotides stabilized by locked nucleic acids;Kurreck;Nucleic Acids Res,2002
5. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates;Straarup;Nucleic Acids Res,2010
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