Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs-Reference-Cited by-同舟云学术

Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs

Published:2023-04-01 Issue:2 Volume:33 Page:83-94
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Takakusa Hideo¹,Iwazaki Norihiko²,Nishikawa Makiya³^ORCID,Yoshida Tokuyuki⁴⁵,Obika Satoshi⁵^ORCID,Inoue Takao⁴⁵

Affiliation:

1. Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

2. Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corp., Yokohama, Japan.

3. Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan.

4. Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Japan.

5. Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2022.0054

Reference76 articles.

1. Therapeutic Oligonucleotides: State of the Art

2. Pharmacology of Antisense Drugs

3. Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

4. Advances in oligonucleotide drug delivery

5. Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

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