Overcoming Challenges in Oligonucleotide Therapeutics Analysis: A Novel Nonion Pair Approach
Author:
Affiliation:
1. Bioanalysis Research Department, CMIC Pharma Science Co., Ltd., Hyogo 677-0032, Japan
2. Division of Medicinal Safety Science, National Institute of Health Sciences, Kanagawa 210-9501, Japan
Funder
Japan Agency for Medical Research and Development
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/jasms.4c00270
Reference13 articles.
1. A perspective on oligonucleotide therapy: Approaches to patient customization
2. Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs
3. Bioanalysis of Oligonucleotide by LC–MS: Effects of Ion Pairing Regents and Recent Advances in Ion-Pairing-Free Analytical Strategies
4. Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry
5. A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples
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