Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches-Reference-Cited by-同舟云学术

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Published:2018-09-12 Issue:5 Volume:104 Page:865-889
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Guo Yingying¹,Chu Xiaoyan²,Parrott Neil J.³,Brouwer Kim L.R.⁴,Hsu Vicky⁵,Nagar Swati⁶,Matsson Pär⁷,Sharma Pradeep⁸,Snoeys Jan⁹,Sugiyama Yuichi¹⁰,Tatosian Daniel²,Unadkat Jashvant D.¹¹,Huang Shiew-Mei⁵,Galetin Aleksandra¹²,

Affiliation:

1. Investigational Drug Disposition; Eli Lilly and Company; Lilly Corporate Center; Indianapolis Indiana, USA

2. Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism; Merck & Co., Inc.; Kenilworth New Jersey, USA

3. Pharmaceutical Sciences; Pharmaceutical Research and Early Development; Roche Innovation Centre Basel; F. Hoffmann-La Roche Ltd.; Basel Switzerland

4. Division of Pharmacotherapy and Experimental Therapeutics; UNC Eshelman School of Pharmacy; The University of North Carolina at Chapel Hill; Chapel Hill North Carolina, USA

5. Office of Clinical Pharmacology; Office of Translational Sciences; Center for Drug Evaluation and Research; US Food and Drug Administration; Silver Spring Maryland, USA

6. Department of Pharmaceutical Sciences; Temple University School of Pharmacy; Philadelphia Pennsylvania, USA

7. Department of Pharmacy; Uppsala University; Uppsala Sweden

8. Safety and ADME Translational Sciences, Drug Safety and Metabolism; IMED Biotech Unit; AstraZeneca R&D; Cambridge UK

9. Department of Pharmacokinetics, Dynamics, and Metabolism; Janssen R&D; Beerse Belgium

10. Sugiyama Laboratory; RIKEN Innovation Center; RIKEN Research Cluster for Innovation; Yokohama Japan

11. Department of Pharmaceutics; University of Washington; Seattle Washington, USA

12. Centre for Applied Pharmacokinetic Research; School of Health Sciences; The University of Manchester; Manchester UK.

Funder

National Institutes of Health

National Institute of General Medical Sciences

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.1183/fullpdf

Reference110 articles.

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3. Development and application of a mechanistic pharmacokinetic model for simvastatin and its active metabolite simvastatin acid using an integrated population pbpk approach;Tsamandouras;Pharm. Res.,2015

4. Transport vs. metabolism: what determines the pharmacokinetics and pharmacodynamics of drugs? Insights from the extended clearance model;Patilea-Vrana;Clin. Pharmacol. Ther.,2016

5. Extended clearance classification system (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters;Varma;Clin. Pharmacol. Ther.,2017

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