Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters-Reference-Cited by-同舟云学术

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters

Published:2017-02-03 Issue:1 Volume:102 Page:33-36
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Varma MV¹,El-Kattan AF²,Feng B¹,Steyn SJ²,Maurer TS²,Scott DO²,Rodrigues AD¹,Tremaine LM¹

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc.; Groton Connecticut USA

2. Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc.; Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference5 articles.

1. EMA http://wwwemaeuropaeu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606pdf 2012

2. http://wwwfdagov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm292362pdf 2012

3. Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS);Varma;Pharm. Res.,2015

4. Projecting ADME behavior and drug-drug interactions in early discovery and development: application of the extended clearance classification system;El-Kattan;Pharm. Res.,2016

5. Transporter-mediated hepatic uptake plays an important role in the pharmacokinetics and drug-drug interactions of montelukast;Varma;Clin. Pharmacol. Ther.,2016

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