Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model
Author:
Affiliation:
1. Department of Pharmaceutics; University of Washington; Seattle Washington USA
Funder
NCATS
NIH
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.437/fullpdf
Reference10 articles.
1. Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?;Endres;Mol. Pharm.,2009
2. Organ clearance concepts: new perspectives on old principles;Sirianni;J. Pharmacokinet. Biopharm.,1997
3. Transporters as a determinant of drug clearance and tissue distribution;Shitara;Eur. J. Pharm. Sci.,2006
4. University of Washington Metabolism and Transport Drug Interaction Database https://www.druginteractioninfo.org/
5. Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study;Maeda;Clin. Pharmacol. Ther.,2011
Cited by 81 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes;Frontiers in Pharmacology;2024-08-07
2. Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain barrier;Drug Metabolism Reviews;2024-07-05
3. PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man;Archives of Toxicology;2024-03-25
4. Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells;Pharmaceutics;2024-02-16
5. Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics‐Informed Relative Expression Factor Approach;Clinical Pharmacology & Therapeutics;2023-12-18
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3