Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model
Author:
Affiliation:
1. Department of Pharmaceutics; University of Washington; Seattle Washington USA
Funder
NCATS
NIH
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.437/fullpdf
Reference10 articles.
1. Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?;Endres;Mol. Pharm.,2009
2. Organ clearance concepts: new perspectives on old principles;Sirianni;J. Pharmacokinet. Biopharm.,1997
3. Transporters as a determinant of drug clearance and tissue distribution;Shitara;Eur. J. Pharm. Sci.,2006
4. University of Washington Metabolism and Transport Drug Interaction Database https://www.druginteractioninfo.org/
5. Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study;Maeda;Clin. Pharmacol. Ther.,2011
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