Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data-Reference-Cited by-同舟云学术

Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

Published:2013-09 Issue:9 Volume:102 Page:3239-3251
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Poulin Patrick,Haddad Sami

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference37 articles.

1. In vitro–in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing methods;Poulin;J Pharm Sci,2012

2. Comparative assessment of in vitro–in vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs;Poulin;J Pharm Sci,2012

3. Evaluation of hepatic clearance prediction using in vitro data: Emphasis of fraction unbound in plasma and drug ionization using a dataset of 107 drugs;Halifax;J Pharm Sci,2012

4. Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes;Sohlenius‐Sternbeck;Xenobiotica,2012

5. Application of in silico, in vitro and pre‐clinical pharmacokinetic data for the effective and efficient prediction of human pharmacokinetics;Krime;Mol. Pharm.,2013

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