Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs-Reference-Cited by-同舟云学术

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs

Published:2012-08 Issue:8 Volume:101 Page:2645-2652
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Hallifax David,Houston J. Brian

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference18 articles.

1. Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems;Hallifax;Curr Drug Met,2009

2. Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake;Baker;Xenobiotica,2007

3. Prediction of hepatic clearance using cryopreserved human hepatocytes: A comparison of serum and serum free incubations;Blanchard;J Pharm Pharmacol,2006

4. Use of intrinsic clearance for prediction of human hepatic clearance;Chao;Expert Opin Drug Metab Toxicol,2010

5. Hepatocyte [3H]-palmitate uptake: Effect of albumin surface charge modification;Burczynski;Can J Physiol Pharmacol,2001

Cited by 51 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio;Journal of Pharmaceutical Sciences;2024-04

2. Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors;ChemMedChem;2023-12-06

3. The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance;Molecular Pharmaceutics;2023-10-09

4. In Vitro–In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In‐depth Case Study with Pyrene;Environmental Toxicology and Chemistry;2023-05-17

5. Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review;Drug Metabolism Reviews;2023-04-12