Genomewide Clonal Analysis of Lethal Mutations in the Drosophila melanogaster Eye: Comparison of the X Chromosome and Autosomes
Author:
Call Gerald B1, Olson John M1, Chen Jiong1, Villarasa Nikki1, Ngo Kathy T1, Yabroff Allison M1, Cokus Shawn1, Pellegrini Matteo1, Bibikova Elena1, Bui Chris1, Cespedes Albert1, Chan Cheryl1, Chan Stacy1, Cheema Amrita K1, Chhabra Akanksha1, Chitsazzadeh Vida1, Do Minh-Tu1, Fang Q Angela1, Folick Andrew1, Goodstein Gelsey L1, Huang Cheng R1, Hung Tony1, Kim Eunha1, Kim William1, Kim Yulee1, Kohan Emil1, Kuoy Edward1, Kwak Robert1, Lee Eric1, Lee JiEun1, Lin Henry1, Liu H-C Angela1, Moroz Tatiana1, Prasad Tharani1, Prashad Sacha L1, Patananan Alexander N1, Rangel Alma1, Rosselli Desiree1, Sidhu Sohrab1, Sitz Daniel1, Taber Chelsea E1, Tan Jingwen1, Topp Kasey1, Tran PhuongThao1, Tran Quynh-Minh1, Unkovic Mary1, Wells Maggie1, Wickland Jessica1, Yackle Kevin1, Yavari Amir1, Zaretsky Jesse M1, Allen Christopher M1, Alli Latifat1, An Ju1, Anwar Abbas1, Arevalo Sonia1, Ayoub Danny1, Badal Shawn S1, Baghdanian Armonde1, Baghdanian Arthur H1, Baumann Sara A1, Becerra Vivian N1, Chan Hei J1, Chang Aileen E1, Cheng Xibin A1, Chin Mabel1, Chong Fleurette1, Crisostomo Carlyn1, Datta Sanjit2, Delosreyes Angela1, Diep Francie1, Ekanayake Preethika1, Engeln Mark1, Evers Elizabeth1, Farshidi Farzin1, Fischer Katrina1, Formanes Arlene J1, Gong Jun1, Gupta Riju1, Haas Blake E1, Hahm Vicky1, Hsieh Michael1, Hui James Z1, Iao Mei L1, Jin Sophia D1, Kim Angela Y1, Kim Lydia S-H1, King Megan3, Knudsen-Robbins Chloe1, Kohanchi David1, Kovshilovskaya Bogdana1, Ku Amy1, Kung Raymond W1, Landig Mark E L1, Latterman Stephanie S1, Lauw Stephanie S1, Lee Daniel S1, Lee Joann S1, Lei Kai C1, Leung Lesley L1, Lerner Renata1, Lin Jian-ya1, Lin Kathleen1, Lim Bryon C1, Lui Crystal P Y1, Liu Tiffany Q1, Luong Vincent1, Makshanoff Jacob1, Mei An-Chi1, Meza Miguel1, Mikhaeil Yara A1, Moarefi Majid1, Nguyen Long H1, Pai Shekhar S1, Pandya Manish1, Patel Aadit R1, Picard Paul D4, Safaee Michael M1, Salame Carol1, Sanchez Christian1, Sanchez Nina1, Seifert Christina C1, Shah Abhishek1, Shilgevorkyan Oganes H1, Singh Inderroop1, Soma Vanessa1, Song Junia J1, Srivastava Neetika1, Sta.Ana Jennifer L1, Sun Christie1, Tan Diane1, Teruya Alison S1, Tikia Robyn1, Tran Trinh1, Travis Emily G1, Trinh Jennifer D1, Vo Diane1, Walsh Thomas1, Wong Regan S1, Wu Katherine1, Wu Ya-Whey1, Yang Nkau X V1, Yeranosian Michael1, Yu James S1, Zhou Jennifer J1, Zhu Ran X1, Abrams Anna1, Abramson Amanda1, Amado Latiffe1, Anderson Jenny1, Bashour Keenan1, Beyer Elsa1, Bookatz Allen1, Brewer Sarah1, Buu Natalie1, Calvillo Stephanie1, Cao Joseph1, Chan Amy1, Chan Jenny1, Chang Aileen1, Chang Daniel1, Chang Yuli1, Chen YiBing1, Choi Joo1, Chou Jeyling1, Dang Peter1, Datta Sumit1, Davarifar Ardy1, Deravanesian Artemis1, Desai Poonam1, Fabrikant Jordan1, Farnad Shahbaz1, Fu Katherine1, Garcia Eddie1, Garrone Nick1, Gasparyan Srpouhi1, Gayda Phyllis1, Go Sherrylene1, Goffstein Chad1, Gonzalez Courtney1, Guirguis Mariam1, Hassid Ryan1, Hermogeno Brenda1, Hong Julie1, Hong Aria1, Hovestreydt Lindsay1, Hu Charles1, Huff Devon1, Jamshidian Farid1, Jen James1, Kahen Katrin1, Kao Linda1, Kelley Melissa1, Kho Thomas1, Kim Yein1, Kim Sarah1, Kirkpatrick Brian1, Langenbacher Adam1, Laxamana Santino1, Lee Janet1, Lee Chris1, Lee So-Youn1, Lee ToHang S1, Lee Toni1, Lewis Gemma1, Lezcano Sheila1, Lin Peter1, Luu Thanh1, Luu Julie1, Marrs Will1, Marsh Erin1, Marshall Jamie1, Min Sarah1, Minasian Tanya1, Minye Helena1, Misra Amit1, Morimoto Miles1, Moshfegh Yasaman1, Murray Jessica1, Nguyen Kha1, Nguyen Cynthia1, Nodado Ernesto1, O'Donahue Amanda1, Onugha Ndidi1, Orjiakor Nneka1, Padhiar Bhavin1, Paul Eric1, Pavel-Dinu Mara1, Pavlenko Alex1, Paz Edwin1, Phaklides Sarah1, Pham Lephong1, Poulose Preethi1, Powell Russell1, Pusic Aya1, Ramola Divi1, Regalia Kirsten1, Ribbens Meghann1, Rifai Bassel1, Saakyan Manyak1, Saarikoski Pamela1, Segura Miriam1, Shadpour Farnaz1, Shemmassian Aram1, Singh Ramnik1, Singh Vivek1, Skinner Emily1, Solomin Daniel1, Soneji Kosha1, Spivey Kristin1, Stageberg Erika1, Stavchanskiy Marina1, Tekchandani Leena1, Thai Leo1, Thiyanaratnam Jayantha1, Tong Maurine1, Toor Aneet1, Tovar Steve1, Trangsrud Kelly1, Tsang Wah-Yung1, Uemura Marc1, Vollmer Emily1, Weiss Emily1, Wood Damien1, Wu Joy1, Wu Sophia1, Wu Winston1, Xu Qing1, Yamauchi Yuki1, Yarosh Will1, Yee Laura1, Yen George1, Banerjee Utpal156
Affiliation:
1. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 2. Palos Verdes Peninsula High School, Rolling Hills Estates, California 90274 3. Culver City Independent Study School, Culver City, California 90230 4. Loyola High School, Los Angeles, California 90006 5. Molecular Biology Institute, University of California, Los Angeles, California 90095 and 6. Department of Biological Chemistry, University of California, Los Angeles, California 90095
Abstract
Abstract
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
Publisher
Oxford University Press (OUP)
Cited by
33 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|