Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket-Reference-Cited by-同舟云学术

Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket

Published:2014-12-05 Issue:1 Volume:86 Page:122-128
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Chen Xuwang¹,Meng Qing¹,Qiu Liyun²,Zhan Peng¹,Liu Huiqing³,De Clercq Erik⁴,Pannecouque Christophe⁴,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry; Key Laboratory of Chemical Biology (Ministry of Education); School of Pharmaceutical Sciences; Shandong University; 44, West Culture Road Ji'nan Shandong 250012 China

2. Department of Pharmacy; Jinan Central Hospital Affiliated to Shandong University; Jinan Shandong 250013 China

3. Institute of Pharmacology; School of Medicine; Shandong University; 44, West Culture Road Ji'nan Shandong 250012 China

4. Rega Institute for Medical Research; KU Leuven; Minderbroedersstraat 10 B-3000 Leuven Belgium

Funder

National Natural Science Foundation of China

NSFC for International Co-Operation

Doctoral Program of Higher Education of China

Natural Science Foundation of Shandong Province

KU Leuven

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12471/fullpdf

Reference15 articles.

1. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine);Janssen;J Med Chem,2005

2. Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1;Guillemont;J Med Chem,2005

3. Recent advances in DAPYs and related analogues as HIV-1 NNRTIs;Chen;Curr Med Chem,2011

4. Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design;Lansdon;J Med Chem,2010

5. Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors;Chen;Bioorg Med Chem Lett,2013

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Medicinal chemistry perspectives on the development of piperazine-containing HIV-1 inhibitors;Bioorganic & Medicinal Chemistry;2024-02

2. Tri‐substituted 1,3,5‐triazine‐based analogs as effective HIV‐1 non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A systematic review;Drug Development Research;2024-02

3. Recent advances in the piperazine based antiviral agents: A remarkable heterocycle for antiviral research;Arabian Journal of Chemistry;2023-12

4. N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor;Journal of Medicinal Chemistry;2023-05-02

5. Pyridine/Pyrimidine Substituted Imidazol-5-one Analogs as HIV-1 RT Inhibitors: Design, Synthesis, Docking and Molecular Dynamic Simulation Studies;Current HIV Research;2021-12-22