Halothane-Anaesthetized, Closed-Chest, Guinea-Pig Model for Assessment of Drug-Induced QT-Interval Prolongation-Reference-Cited by-同舟云学术

Halothane-Anaesthetized, Closed-Chest, Guinea-Pig Model for Assessment of Drug-Induced QT-Interval Prolongation

Published:2009-01 Issue:1 Volume:104 Page:43-48
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:

Author:

Sakaguchi Yasue,Takahara Akira,Nakamura Yuji,Akie Yasuki,Sugiyama Atsushi

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference15 articles.

1. Drug-induced torsades de pointes and implications for drug development;Fenichel;J Cardiovasc Electrophysiol,2004

2. 2ICH Harmonized Tripartite Guideline: The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization QT Interval Prolongation) by Human Pharmaceuticals (S7B). Recommended for adoption at step 4 of the ICH process. http://www.ich.org/12 May 2005.

3. Halothane sensitizes the guinea-pig heart to pharmacological IKr blockade: comparison with urethane anesthesia;Sakaguchi;J Pharmacol Sci,2005

4. Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation;Takahara;Br J Pharmacol,2005

5. Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation;Takahara;Biol Pharm Bull,2006

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