Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model

Author:

Cao Xin,Nagasawa Yoshinobu,Zhang Chengshun,Zhang Hanxiao,Aimoto Megumi,Takahara Akira

Funder

National Natural Science Foundation of China

Sichuan Science and Technology Program

Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Research Fund

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine

Reference26 articles.

1. Efficacy of intravenous acehytisine hydrochloride versus propafenone on terminating paroxysmal supraventricular tachycardia: a double-blinded, randomized multi-center study;Gao;Zhonghua Xinxueguanbing Zazhi,2007

2. Atrial-selective block of sodium channels by acehytisine in rabbit myocardium;Fan;J Pharmacol Sci,2016

3. Antiarrhythmic ionic mechanism of guanfu base A−Selective inhibition of late sodium current in isolated ventricular myocytes from Guinea pigs;Jin;Chin J Nat Med,2015

4. Effects of guanfu base a hydrochloride on heart L-type calcium channel of rat ventricular myocytes;Gao;Chin J N Drugs,2006

5. The effects of a novel anti-arrhythmic drug, acehytisine hydrochloride, on the human ether-a-go-go relat ed gene K channel and its trafficking;Huang;Basic Clin Pharmacol Toxicol,2009

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