Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia

Author:

Sakaguchi Yasue,Sugiyama Atsushi,Takao Shuji,Akie Yasuki,Takahara Akira,Hashimoto Keitaro

Publisher

Japanese Pharmacological Society

Subject

Pharmacology,Molecular Medicine

Reference18 articles.

1. 1 The ICH Steering Committee. The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. The international conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH). The guideline was recommended for adoption at Step 4 of the ICH process on 12 May 2005 (http://www.ich.org/).

2. Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

3. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk

4. Halothane sensitizes the canine heart to pharmacological IKr blockade

5. The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart

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