Characterization of the Halothane-Anesthetized Guinea-Pig Heart as a Model to Detect the K+ Channel Blocker-Induced QT-Interval Prolongation
Author:
Affiliation:
1. Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
http://www.jstage.jst.go.jp/article/bpb/29/4/29_4_827/_pdf
Reference15 articles.
1. Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B
2. The role of the delayed rectifier component I Ks in dog ventricular muscle and Purkinje fibre repolarization
3. Pharmacological block of the slow component of the outward delayed rectifier current (I Ks ) fails to lengthen rabbit ventricular muscle QTc and action potential duration
4. Restricting Excessive Cardiac Action Potential and QT Prolongation
5. Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve
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