Intracellular Carboxyl Esterase Activity Is a Determinant of Cellular Sensitivity to the Antineoplastic Agent KW-2189 in Cell Lines Resistant to Cisplatin and CPT-11

Author:

Ogasawara Hayato,Nishio Kazuto,Kanzawa Fumihiko,Lee Yong-Sik,Funayama Yasunori,Ohira Tatsuo,Kuraishi Yasunobu,Isogai Yukihide,Saijo Nagahiro

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference15 articles.

1. Anticellular and antitumor activity of duocarmycins, novel antitumor antibiotics;Gomi;Jpn. J. Cancer Res.,1992

2. Characteristics of antitumor activity of KW-2189, a novel water-soluble derivative of duocarmycin, against murine and human tumors;Kobayashi;Cancer Res.,1994

3. A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells;Ogasawara;Jpn. J. Cancer Res.,1994

4. Effects of KW-2189 on MOLT-3 human leukemia and HT-29 colon carcinoma cells;Arkin;Proc. Am. Assoc. Cancer Res.,1994

5. Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin;Niimi;Cancer Res.,1992

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