A Novel Antitumor Antibiotic, KW-2189 Is Activated by Carboxyl Esterase and Induces DNA Strand Breaks in Human Small Cell Lung Cancer Cells

Author:

Ogasawara Hayato,Nishio Kazuto,Takeda Yuichiro,Ohmori Tohru,Kubota Naohiro,Funayama Yasunori,Ohira Tatsuo,Kuraishi Yasunobu,Isogai Yukihide,Saijo Nagahiro

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference26 articles.

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2. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin;Hsiang;Cancer Res.,1988

3. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11;Kawato;Cancer Res.,1991

4. CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer;Masuda;J. Clin. Oncol.,1992

5. Phase II study of CPT-11, new camptothecin derivative, in the patients with metastatic colorectal cancer;Shimada;Proc. Am. Soc. Clin. Oncol.,1991

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