Synthesis, cytotoxic evaluation and target identification of thieno[2,3- d ]pyrimidine derivatives with a dithiocarbamate side chain at C2 position-Reference-Cited by-同舟云学术

Synthesis, cytotoxic evaluation and target identification of thieno[2,3- d ]pyrimidine derivatives with a dithiocarbamate side chain at C2 position

Published:2018-06 Issue: Volume:154 Page:324-340
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Yang Chao-Rui,Peng Bin,Cao Sheng-Li,Ren Ting-Ting,Jiang Wei,Wang Fu-Cheng,Li You-Shan,Wang Guo,Li Zheng,Xu Shibin,Liao Ji,Wang Hailong,Li Jing,Xu Xingzhi

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Commission

Capacity Building for Sci-Tech Innovation - Fundamental Scientific Research Funds

Shenzhen University Health Science Centre

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference36 articles.

1. Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry†

2. Structural modifications at the 6-position of thieno[2,3-d]pyrimidines and their effects on potency at FLT3 for treatment of acute myeloid leukemia;Kim;Eur. J. Med. Chem.,2016

3. Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors;Yang;Bioorg. Med. Chem.,2014

4. New potent SARS-CoV 3C-like protease inhibitors derived from thieno[2,3-d]pyrimidine derivatives;Abd El-All;Arch. Pharm. Chem. Life Sci.,2016

5. Design, synthesis, characterization, quantum-chemical calculations and anti-inflammatory activity of novel series of thiophene derivatives;Helal;Spectrochim. Acta A Mol. Biomol. Spectrosc.,2015

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