Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors-Reference-Cited by-同舟云学术

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Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors

Published:2020-04 Issue: Volume:191 Page:112120
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Hilton-Proctor J.P.,Ilyichova O.,Zheng Z.,Jennings I.G.,Johnstone R.W.,Shortt J.,Mountford S.J.,Scanlon M.J.,Thompson P.E.

Funder

Monash Institute of Pharmaceutical Sciences

Cancer Council Victoria Venture Grant

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference55 articles.

1. The rise of fragment-based drug discovery;Murray;Nat. Chem.,2009

2. Twenty years on: the impact of fragments on drug discovery;Erlanson;Nat. Rev. Drug Discov.,2016

3. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia;Raheem;Bioorg. Med. Chem. Lett,2016

4. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains;Hay;J. Am. Chem. Soc.,2014

5. Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors;Casale;Bioorg. Med. Chem.,2014

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