Catalytic, asymmetric azidations at carbonyls: achiral and <i>meso</i>-anhydride desymmetrisation affords enantioenriched γ-lactams-Reference-Cited by-同舟云学术

Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched γ-lactams

Published:2022 Issue:32 Volume:20 Page:6384-6393
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Smith Simon N.¹^ORCID,Trujillo Cristina¹^ORCID,Connon Stephen J.¹^ORCID

Affiliation:

1. Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland

Abstract

The first catalytic asymmetric addition of azide to carbonyl centres has been reported – a hypermodified Cinchona alkaloid-derived organocatalyst promotes the addition of trimethylsilyl azide to glutaric anhydrides.

Funder

Irish Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01040B

Reference82 articles.

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