Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues-Reference-Cited by-同舟云学术

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

Published:2011-12 Issue:12 Volume:46 Page:6119-6130
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Martins Carla,Carreiras M. Carmo,León Rafael,de los Ríos Cristóbal,Bartolini Manuela,Andrisano Vincenza,Iriepa Isabel,Moraleda Ignacio,Gálvez Enrique,García Manuela,Egea Javier,Samadi Abdelouhaid,Chioua Mourad,Marco-Contelles José

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

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1. Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer’s Disease

2. Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

3. Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

4. Designed Multiple Ligands. An Emerging Drug Discovery Paradigm

5. Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

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