1. Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy, Laboratoire de Physique et Biophysique, GESVAB EA3675 ISVV, University of Bordeaux 2, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France, and Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy