Complementary asymmetric routes to fused tricyclic (R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinolines and (R)-1,2,3,4,5,5a,6,7-octahydro-[1,4]diazepino[1,2-a]quinolines-Reference-Cited by-同舟云学术

Complementary asymmetric routes to fused tricyclic (R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinolines and (R)-1,2,3,4,5,5a,6,7-octahydro-[1,4]diazepino[1,2-a]quinolines

Published:2016-10 Issue:42 Volume:57 Page:4730-4733
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Schrader Thomas O.,Kasem Michelle,Sun Qi,Wu Chunrui,Ren Albert,Semple Graeme

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference29 articles.

1. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

2. 3D Molecular Descriptors Important for Clinical Success

3. Escape from Flatland 2: complexity and promiscuity

4. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

5. Beyond Size, Ionization State, and Lipophilicity: Influence of Molecular Topology on Absorption, Distribution, Metabolism, Excretion, and Toxicity for Druglike Compounds

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor;Bioorganic & Medicinal Chemistry Letters;2021-04

2. Recent synthetic methodologies for the tricyclic fused-quinoline derivatives;Synthetic Communications;2020-09-08

3. Convergent Formal Synthesis of Ecteinascidin 743;The Journal of Organic Chemistry;2019-09-16

4. Asymmetric syntheses of (R)-4-halo-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines, important 5-HT2C agonist precursors;Tetrahedron Letters;2018-05

5. Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor;Bioorganic & Medicinal Chemistry Letters;2016-12