Beyond Size, Ionization State, and Lipophilicity: Influence of Molecular Topology on Absorption, Distribution, Metabolism, Excretion, and Toxicity for Druglike Compounds-Reference-Cited by-同舟云学术

Beyond Size, Ionization State, and Lipophilicity: Influence of Molecular Topology on Absorption, Distribution, Metabolism, Excretion, and Toxicity for Druglike Compounds

Published:2012-04-17 Issue:8 Volume:55 Page:3667-3677
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Yidong¹,Engkvist Ola¹,Llinàs Antonio¹,Chen Hongming¹

Affiliation:

1. Discovery Sciences, Computational Sciences, Computational Chemistry, and ‡R&I iMED, In Vitro & In Vivo ADME, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201548z

Reference53 articles.

1. Managing the drug discovery/development interface

2. Drug research: myths, hype and reality

3. Why Drugs Fail - A Study on Side Effects in New Chemical Entities

4. Can the pharmaceutical industry reduce attrition rates?

5. The price of innovation: new estimates of drug development costs

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