HLM chip – A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes-Reference-Cited by-同舟云学术

HLM chip – A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes

Published:2024-06 Issue: Volume:197 Page:106773
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Pihlaja Tea,Kiiski Iiro,Sikanen Tiina^ORCID

Funder

Research Council of Finland

Strategic Research Council

Publisher

Elsevier BV

Reference47 articles.

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3. Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination;Brown;Drug Metab. Dispos.,2007

4. Pitfalls in the design of metabolism-dependent CYP inhibition (MDI) experiments with a dilution step: inhibitor depletion by metabolism and/or microsomal binding leads to underestimation of the shifted IC50 value;Buckley;Drug Metab. Rev.,2010

5. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors;Coan;J. Am. Chem. Soc.,2008

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1. Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol–ene micropillar arrays;Lab on a Chip;2024