Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes forKiDetermination-Reference-Cited by-同舟云学术

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Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes forKiDetermination

Published:2007-08-27 Issue:11 Volume:35 Page:2119-2126
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Brown Hayley S.,Chadwick Anthony,Houston J. Brian

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference41 articles.

1. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

2. HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

3. Prediction of In Vivo Drug-Drug Interactions from In Vitro Data

4. Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

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1. HLM chip – A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes;European Journal of Pharmaceutical Sciences;2024-06

2. Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion;Oral Bioavailability and Drug Delivery;2023-10-10

3. Evaluation of Zuo-Gui Yin Decoction Effects on Six CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS;BioMed Research International;2022-08-26

4. Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam;Xenobiotica;2019-03-05

5. Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method;Drug Metabolism and Disposition;2018-02-14

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