Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors-Reference-Cited by-同舟云学术

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors

Published:2011-05 Issue:9 Volume:21 Page:2752-2755
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Beck Hilary P.,DeGraffenreid Michael,Fox Brian,Allen John G.,Rew Yosup,Schneider Stephen,Saiki Anne Y.,Yu Dongyin,Oliner Jonathan D.,Salyers Kevin,Ye Qiuping,Olson Steven

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. The genetics of the p53 pathway, apoptosis and cancer therapy

2. Control of apoptosis by p53

3. Mdm2 promotes the rapid degradation of p53

4. Regulation of p53 stability by Mdm2

5. p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

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