Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease-Reference-Cited by-同舟云学术

Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease

Published:2015-03 Issue:5 Volume:25 Page:1086-1091
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fukunaga Kenji,Sakai Daiki,Watanabe Kazutoshi,Nakayama Kazuki,Kohara Toshiyuki,Tanaka Hiroshi,Sunada Shinji,Nabeno Mika,Okamoto Masako,Saito Ken-Ichi,Eguchi Jun-ichi,Mori Akiko,Tanaka Shinji,Inazawa Keiko,Horikawa Takashi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

2. Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease: From Pathology to Treatment Target

3. Tau protein kinases: Involvement in Alzheimer's disease

4. The Pharmacoeconomics of Cognitive Enhancers in Moderate to Severe Alzheimerʼs Disease

5. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors

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