Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2959.pdf
Reference137 articles.
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3. Kidd, M. Paired helical filaments in electron microscopy of alzheimers disease. Nature 197, 192–193 (1963). The first description of PHFs in Alzheimer's disease neurofibrillary tangles at the electron microscope level.
4. Arriagada, P. V., Growdon, J. H., Hedleywhyte, E. T. & Hyman, B. T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimers disease. Neurology 42, 631–639 (1992). This study showed that tangles, not plaques, correlate with dementia severity in Alzheimer's disease.
5. Wilcock, G. K. & Esiri, M. M. Plaques, tangles and dementia — a quantitative study. J. Neurological. Sci. 56, 343–356 (1982).
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