Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-<i>b</i>]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors-Reference-Cited by-同舟云学术

Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors

Published:2023-03-09 Issue:6 Volume:66 Page:4231-4252
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hartz Richard A.^ORCID,Ahuja Vijay T.,Sivaprakasam Prasanna^ORCID,Xiao Hong,Krause Carol M.,Clarke Wendy J.,Kish Kevin,Lewis Hal,Szapiel Nicolas,Ravirala Ramu¹,Mutalik Sayali¹,Nakmode Deepa¹,Shah Devang¹,Burton Catherine R.,Macor John E.,Dubowchik Gene M.

Affiliation:

1. Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore 560099, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00133

Reference69 articles.

1. A Hundred Years of Alzheimer's Disease Research

2. 2020 Alzheimer's disease facts and figures

3. Glycogen Synthase Kinase 3 (GSK3): Its Role and Inhibitors

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