Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties-Reference-Cited by-同舟云学术

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties

Published:2008-08 Issue:16 Volume:18 Page:4503-4507
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Regan Colin F.,Guo Zhiqiang,Chen Yongsheng,Huang Charles Q.,Chen Mi,Jiang Wanlong,Rueter Jaimie K.,Coon Timothy,Chen Chen,Saunders John,Brown Michael S.,Betz Steve F.,Struthers R. Scott,Yang Chun,Wen Jenny,Madan Ajay,Zhu Yun-Fei

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference9 articles.

1. GnRH Agonists and Antagonists in Cancer Therapy

2. Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists

3. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization

4. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity

5. Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers

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