Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity-Reference-Cited by-同舟云学术

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity

Published:2008-06 Issue:11 Volume:18 Page:3301-3305
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Chen Chen,Chen Yongsheng,Pontillo Joseph,Guo Zhiqiang,Huang Charles Q.,Wu Dongpei,Madan Ajay,Chen Takung,Wen Jenny,Xie Qiu,Tucci Fabio C.,Rowbottom Martin,Zhu Yun-Fei,Wade Warren,Saunders John,Bozigian Haig,Struthers R. Scott

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. High throughput P450 inhibition screens in early drug discovery

2. Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers

3. Trapping of a Nonpeptide Ligand by the Extracellular Domains of the Gonadotropin-Releasing Hormone Receptor Results in Insurmountable Antagonism

4. Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

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