3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization-Reference-Cited by-同舟云学术

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization

Published:2005-01-25 Issue:4 Volume:48 Page:1169-1178
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tucci Fabio C.¹,Zhu Yun-Fei¹,Struthers R. Scott¹,Guo Zhiqiang¹,Gross Timothy D.¹,Rowbottom Martin W.¹,Acevedo Oscar¹,Gao Yinghong¹,Saunders John¹,Xie Qiu¹,Reinhart Greg J.¹,Liu Xin-Jun¹,Ling Nicholas¹,Bonneville Anne K. L.¹,Chen Takung¹,Bozigian Haig¹,Chen ¹

Affiliation:

1. Departments of Medicinal Chemistry, Endocrinology, and Preclinical Development, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, California 92130

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049218c

Reference34 articles.

1. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence

2. Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)

3. Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor

4. Gonadotropin-Releasing Hormone Receptors

5. The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor

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