Identification of the metabolites of XL092 in rat and human by using ultra-high performance liquid chromatography high resolution mass spectrometry
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry
Reference14 articles.
1. XL092, a multi-targeted inhibitor of MET, VEGFR2, AXL and MER with an optimized pharmacokinetic profile;Hsu;Eur. J. Cancer,2020
2. 〈https://clinicaltrials.gov/ct2/show/NCT03845166?cond=XL092&draw=2&rank=1〉.
3. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States;Stepan;Chem. Res Toxicol.,2011
4. Metabolic activation of carboxylic acids;Skonberg;Expert Opin. Drug Metab. Toxicol.,2008
5. Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs;Miyashita;Drug Metab. Dispos.,2014
Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A simple and sensitive liquid chromatography triple quadrupole mass spectrometry method for the determination of XL092 in monkey plasma and its application to pharmacokinetic study;Biomedical Chromatography;2024-01-30
2. Metabolic profiling of Qi‐Yu‐San‐Long decoction in rat feces by ultraperformance liquid chromatography–quadrupole time‐of‐flight mass spectrometry combined with a post‐targeted screening strategy;Biomedical Chromatography;2023-09-25
3. Rapid determination of 48 stimulant residues in milk and dairy products by high-performance liquid chromatography coupled with quadrupole/Orbitrap high-resolution mass spectrometry;Chemical Papers;2023-05-19
4. High‐resolution accurate mass approach to characterization of SCO‐267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry;Rapid Communications in Mass Spectrometry;2022-05-27
5. Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive plus mass spectrometrys;Xenobiotica;2022-03-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3