Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States-Reference-Cited by-同舟云学术

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Published:2011-07-11 Issue:9 Volume:24 Page:1345-1410
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Stepan Antonia F.¹²,Walker Daniel P.¹²,Bauman Jonathan¹²,Price David A.¹²,Baillie Thomas A.¹²,Kalgutkar Amit S.¹²,Aleo Michael D.¹²

Affiliation:

1. Worldwide Medicinal Chemistry, ‡Pharmacokinetics, Dynamics and Metabolism, and §Investigative Toxicology, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

2. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, 98195

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx200168d

Reference392 articles.

1. Pharmacogenetics of drug hypersensitivity

2. Animal models of idiosyncratic drug reactions

3. Brief history of chemical carcinogenesis

4. The Metabolism of Xenobiotics to Reactive Electrophiles in Chemical Carcinogenesis and Mutagenesis: A Collaboration with Elizabeth Cavert Miller and our Associates

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