High‐resolution accurate mass approach to characterization of SCO‐267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry-Reference-Cited by-同舟云学术

High‐resolution accurate mass approach to characterization of SCO‐267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry

Published:2022-05-27 Issue:14 Volume:36 Page:
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Comm Mass Spectrometry

Author:

Zhu Ying¹,Wang Ting²,Zhao Na²,Jiang Wenya²^ORCID

Affiliation:

1. Department of Pharmacy Xuzhou Central Hospital Jiangsu Province Xuzhou China

2. Department of Pharmacy Zhangjiagang Hospital of Traditional Chinese Medicine Jiangsu Province Zhangjiagang China

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/rcm.9325

Reference22 articles.

1. The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

2. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

3. Fasiglifam as a new potential treatment option for patients with type 2 diabetes

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1. Evidence for cytochrome P450 3A4‐mediated metabolic activation of SCO‐267;Biopharmaceutics & Drug Disposition;2024-01-18

2. Preclinical pharmacokinetics and metabolism study of SCO‐267, a GPR40 full agonist, in beagle dogs using ultra‐high performance liquid chromatography coupled to tandem mass spectrometry;Biomedical Chromatography;2023-05-26

3. Learn from failures and stay hopeful to GPR40, a GPCR target with robust efficacy, for therapy of metabolic disorders;Frontiers in Pharmacology;2022-10-25