A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions-Reference-Cited by-同舟云学术

A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions

Published:2021-07 Issue:7 Volume:110 Page:2841-2858
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Poulin Patrick,Haddad Sami^ORCID

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference29 articles.

1. Prediction of human clearance of twentynine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes;Obach;Drug Metab Dispos,1999

2. Improving prediction of metabolic clearance using quantitative extrapolation of results obtained from human hepatic MPCC model and by considering the impact of albumin binding;Da-silva;J Pharm Sci,2018

3. Organic anion transporter 2-mediated hepatic uptake contributes to the clearance of high-permeability-low-molecular-weight acid and zwitterion drugs: evaluation using 25 drugs;Kimoto;J Pharmacol Exp Ther,2018

4. The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular and intracellular tissue water and the corresponding corrected PBPK equation;Berezhkovskiy;J Pharm Sci,2011

5. The role of extracellular binding proteins in the cellular uptake of drugs: impact on quantitative In Vitro-to-In Vivo extrapolations of toxicity and efficacy in physiologically based pharmacokinetic-pharmacodynamic research;Poulin;J Pharm Sci,2016

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An Overview of Interpretability of Two Models of Unbound Fraction that are Used in Combination with the Well-Stirred Model for Predicting Hepatic Clearance of Drugs;Journal of Pharmaceutical Sciences;2024-09

2. First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics;Journal of Pharmaceutical Sciences;2024-08

3. Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake;Drug Metabolism and Disposition;2024-04-11

4. Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats;Heliyon;2024-03

5. Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation;Environmental Science & Technology;2023-11-27