Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding-Reference-Cited by-同舟云学术

Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding

Published:2018-07 Issue:7 Volume:107 Page:1957-1972
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Da-silva Franck,Boulenc Xavier,Vermet Hélène,Compigne Pauline,Gerbal-Chaloin Sabine,Daujat-Chavanieu Martine,Klieber Sylvie,Poulin Patrick

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference59 articles.

1. Predicting clearance in humans from in vitro data;Obach;Curr Top Med Chem,2011

2. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes;Smith;J Pharm Sci,2012

3. Human hepatocytes in primary culture: the choice to investigate drug metabolism in man;Gomez-Lechon;Curr Drug Metab,2004

4. Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes;Vinci;Biotechnol J,2011

5. Liver tissue engineering in the evaluation of drug safety;Dash;Expert Opin Drug Metab Toxicol,2009

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An Overview of Interpretability of Two Models of Unbound Fraction that are Used in Combination with the Well-Stirred Model for Predicting Hepatic Clearance of Drugs;Journal of Pharmaceutical Sciences;2024-09

2. Liver-on-chips for drug discovery and development;Materials Today Bio;2024-08

3. First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics;Journal of Pharmaceutical Sciences;2024-08

4. Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation;Drug Metabolism and Disposition;2023-09-26

5. Exploring the Boundaries for In Vitro–In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types;Drug Metabolism and Disposition;2023-08-14