Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake-Reference-Cited by-同舟云学术

Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake

Published:2024-04-11 Issue:6 Volume:52 Page:548-554
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Yan Zhengyin,Ma Li,Hwang Nicky,Huang Julie,Kenny Jane R.,Hop Cornelis E.C.A.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Reference34 articles.

1. Non-invasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agent

2. Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue

3. Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake

4. HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview;Balasubramanian;Curr Drug Metab,2021

5. Some features of the kinetics and equilibrium of drug binding to plasma proteins;Berezhkovskiy;Expert Opin Drug Metab Toxicol,2008

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1. An Overview of Interpretability of Two Models of Unbound Fraction that are Used in Combination with the Well-Stirred Model for Predicting Hepatic Clearance of Drugs;Journal of Pharmaceutical Sciences;2024-09

2. Understanding plasma protein binding of drugs: Considering complexity and binding dynamics;Journal of Pharmaceutical Sciences;2024-09

3. Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance;Molecular Pharmaceutics;2024-08-21

4. First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics;Journal of Pharmaceutical Sciences;2024-08