Improving the metabolic fidelity of cancer models with a physiological cell culture medium-Reference-Cited by-同舟云学术

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

Published:2019-01-04 Issue:1 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Vande Voorde Johan¹^ORCID,Ackermann Tobias¹^ORCID,Pfetzer Nadja¹,Sumpton David¹^ORCID,Mackay Gillian¹,Kalna Gabriela¹,Nixon Colin¹^ORCID,Blyth Karen¹²,Gottlieb Eyal¹³,Tardito Saverio¹²^ORCID

Affiliation:

1. Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G611BD, UK.

2. Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

3. Technion Integrated Cancer Center, Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel.

Abstract

Plasmax, a physiological cell culture medium, prevents metabolic artifacts imposed on cancer cells by commonly used media.

Funder

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

1. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

2. Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

3. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma;Tardito S.;Nat. Cell Biol.,2015

4. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition;Muir A.;eLife,2017

5. The nutrient environment affects therapy

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