Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models

Author:

Hammond Nia G.,Cameron Robert B.,Faubert Brandon

Abstract

AbstractAdvances in cancer biology have highlighted metabolic reprogramming as an essential aspect of tumorigenesis and progression. However, recent efforts to study tumor metabolism in vivo have identified some disconnects between in vitro and in vivo biology. This is due, at least in part, to the simplified nature of cell culture models and highlights a growing need to utilize more physiologically relevant approaches to more accurately assess tumor metabolism. In this review, we outline the evolution of our understanding of cancer metabolism and discuss some discrepancies between in vitro and in vivo conditions. We describe how the development of physiological media, in combination with advanced culturing methods, can bridge the gap between in vitro and in vivo metabolism.

Funder

National Cancer Institute, United States

National Institute General Medical Sciences, United States

Cancer Research Foundation

Publisher

Springer Science and Business Media LLC

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